Glimepiride 3 mg+ Metformin 850 mg
Price range: $90.00 through $170.00
| Quantity Value | Price | Price/Unit | Quantity | Add To Cart |
|---|---|---|---|---|
| 100 Tablet S | $90.00 | $0.90 / Piece |
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| 200 Tablets | $170.00 | $0.85 / Piece |
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SKU : N/A
Category : Other
Glimepiride 3 mg + Metformin 850 mg
Glimepiride 3 mg + Metformin 850 mg is a combination oral antidiabetic medicine used to improve blood-glucose control in people with type 2 diabetes mellitus when treatment with diet, exercise, or a single medicine does not provide adequate control.
The combination contains two medicines with complementary actions. Glimepiride belongs to the sulfonylurea group, while metformin belongs to the biguanide group. Together, they help lower blood glucose through different mechanisms.
Uses
Glimepiride 3 mg + Metformin 850 mg may be prescribed for:
- Type 2 diabetes mellitus
- Inadequate blood-sugar control with metformin or another single antidiabetic medicine
- Patients requiring combination therapy to achieve individualized glucose targets
- Improving both fasting and post-meal blood-glucose levels
This medicine is generally used along with a balanced diet, appropriate physical activity, weight management, and regular diabetes monitoring.
It is not used to treat type 1 diabetes or diabetic ketoacidosis.
How It Works
The two components work differently.
Glimepiride
Glimepiride stimulates the pancreas to release more insulin. The additional insulin helps move glucose from the bloodstream into cells, thereby lowering blood sugar.
Because glimepiride increases insulin release, it can cause hypoglycemia, particularly if meals are skipped, food intake is inadequate, alcohol is consumed, or the dose is too high.
Metformin
Metformin primarily reduces glucose production by the liver and improves the body’s sensitivity to insulin. This allows tissues to use glucose more effectively.
Metformin generally has a low risk of hypoglycemia when used alone, but the risk increases when it is combined with glimepiride.
How to Take
Take this combination exactly as prescribed by your doctor. It is generally taken with or immediately after a meal to reduce stomach upset and help coordinate glimepiride’s glucose-lowering effect with food intake.
Take the tablet with water and swallow it as directed. Try to take it at the same time each day.
Do not skip meals after taking glimepiride unless your healthcare professional has given you specific instructions. If you miss a dose, do not take an extra dose to compensate without medical advice.
The appropriate dose depends on blood-glucose levels, kidney and liver function, age, diet, and response to treatment. Do not change the dose yourself.
Common Side Effects
Possible side effects include:
- Nausea
- Diarrhea
- Abdominal discomfort
- Bloating or gas
- Headache
- Dizziness
- Increased appetite
- Weight gain
Digestive symptoms are more commonly associated with metformin and may improve as the body adjusts to treatment.
Low Blood Sugar (Hypoglycemia)
Hypoglycemia is one of the most important risks because of glimepiride.
Symptoms may include:
- Sweating
- Shaking
- Hunger
- Fast heartbeat
- Dizziness
- Weakness
- Headache
- Irritability or confusion
- Blurred vision
- Difficulty concentrating
If you are conscious and experiencing symptoms of low blood sugar, promptly consume a rapidly absorbed source of glucose, such as glucose tablets or a sugary drink, according to your diabetes-management plan. Recheck your blood sugar if possible and seek medical advice if symptoms are severe, recurrent, or do not improve.
Severe hypoglycemia can cause seizures or loss of consciousness and requires emergency treatment.
Lactic Acidosis
Metformin has a rare but potentially serious complication called lactic acidosis, in which lactic acid accumulates in the blood.
The risk is increased with significant kidney impairment and certain serious medical conditions. Seek urgent medical attention for severe weakness, unusual sleepiness, difficulty breathing, persistent vomiting, severe abdominal discomfort, muscle pain, or feeling unusually cold.
Kidney function should therefore be assessed before and periodically during treatment.
Vitamin B12 Deficiency
Long-term metformin treatment can reduce vitamin B12 levels in some patients. Your healthcare professional may recommend periodic testing, especially during prolonged treatment or if you develop anemia, persistent fatigue, numbness, or tingling.
Precautions
Tell your doctor if you have:
- Kidney disease
- Liver disease
- Heart failure or significant heart disease
- A history of severe hypoglycemia
- Adrenal or pituitary disorders
- Heavy alcohol consumption
- Severe infection or dehydration
- Poor nutritional intake
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency
Older adults may be more vulnerable to hypoglycemia and may require careful dose adjustment.
Avoid excessive alcohol consumption because it can increase the risk of hypoglycemia from glimepiride and may increase the risk of lactic acidosis associated with metformin.
Drug Interactions
This combination can interact with medicines that alter blood glucose or affect the action of either component. Examples include:
- Insulin and other antidiabetic medicines
- Beta-blockers, which may mask some symptoms of hypoglycemia
- Corticosteroids, which can increase blood glucose
- Certain diuretics
- ACE inhibitors and some other medicines that can alter glucose control
- Alcohol
- Warfarin and certain other medicines whose effects may be altered by glimepiride
- Iodinated contrast agents used for certain imaging procedures
Always tell your doctor or pharmacist about prescription medicines, over-the-counter products, vitamins, and herbal supplements you use.
Kidney Function and Contrast Procedures
Metformin is eliminated primarily through the kidneys. Significant kidney impairment may require dose adjustment or make metformin-containing treatment inappropriate.
If you are scheduled for a procedure involving iodinated contrast material, inform your healthcare team that you take metformin. Depending on your kidney function and the procedure, temporary interruption may be necessary.
During severe dehydration, prolonged vomiting or diarrhea, serious infection, or other acute illnesses, contact your healthcare professional for advice about continuing treatment.
Pregnancy and Breastfeeding
This combination is generally not the preferred treatment during pregnancy because glimepiride can cause maternal and fetal complications related to blood-glucose lowering. If you are pregnant or planning pregnancy, speak with your doctor about the most appropriate diabetes treatment.
Glimepiride and metformin can pass into breast milk. Breastfeeding patients should discuss treatment with their healthcare professional, particularly because sulfonylureas may cause hypoglycemia in a breastfed infant.
Monitoring
Your doctor may regularly monitor:
- Fasting and post-meal blood glucose
- HbA1c
- Kidney function
- Liver function when appropriate
- Body weight
- Vitamin B12 during long-term metformin treatment when indicated
- Symptoms or episodes of hypoglycemia
Regular meals, physical activity, and appropriate dietary planning are important parts of treatment.
Storage
Store the tablets at room temperature, away from excessive heat and moisture. Keep them in their original packaging and out of reach of children. Do not use the medicine after its expiry date.
Conclusion
Glimepiride 3 mg + Metformin 850 mg combines two complementary medicines for the management of type 2 diabetes. Glimepiride increases insulin release from the pancreas, while metformin reduces liver glucose production and improves insulin sensitivity.
The most important safety concern is hypoglycemia, particularly if meals are skipped or the medicine is combined with other glucose-lowering treatments. Metformin also requires attention to kidney function because of the rare risk of lactic acidosis. Take the combination with meals and exactly as prescribed, maintain regular glucose monitoring, and do not change the dose without medical advice.
| Pack Size |
100 Tablet/s ,200 Tablets |
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