Pirfenex 200 Mg
$10.50 – $900.00
| Quantity Value | Price | Quantity | Add To Cart |
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| 10 Tablet/s | $10.50 |
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| 30 Tablet/s | $29.40 |
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| 50 Tablet/s | $48.50 |
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| 100 Tablet/s | $96.50 |
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| 200 Tablet/s | $188.50 |
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| 300 Tablet/s | $285.00 |
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| 500 Tablet/s | $470.00 |
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| 1000 Tablet/s | $900.00 |
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SKU : Pirfenex 200 Mg
Category : Pirfenidone , Viral Care
Pirfenex 200 Mg is used to treat idiopathic pulmonary fibrosis (IPF). It helps slow lung scarring, improves breathing, and enhances overall lung function.
Pirfenex 200 mg is a prescription-based oral medication used for the treatment of Idiopathic Pulmonary Fibrosis (IPF), a chronic and life-altering lung disease that leads to progressive scarring of lung tissue. Manufactured by Cipla Ltd., Pirfenex contains Pirfenidone, an anti-fibrotic and anti-inflammatory agent that helps slow the progression of fibrosis, offering patients better control over the debilitating symptoms of IPF. With early intervention and consistent use, Pirfenex 200 mg helps preserve lung function and enhances the overall quality of life for affected individuals.
What Is Idiopathic Pulmonary Fibrosis (IPF)?
IPF is a rare but serious condition where the lung tissues become scarred over time without any known cause. This scarring, or fibrosis, makes it increasingly difficult for the lungs to function properly, ultimately reducing oxygen delivery to the bloodstream. Patients experience symptoms such as chronic dry cough, breathlessness, fatigue, and reduced exercise tolerance. IPF tends to worsen over time and, without treatment, can lead to severe respiratory failure.
Pirfenex 200 mg has emerged as a critical component in the management of IPF by slowing the rate of lung scarring and extending patient survival. While it is not a cure, it plays a vital role in disease control and symptom relief.
Composition and Formulation
Each tablet of Pirfenex 200 mg contains:
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Pirfenidone – 200 mg as the active pharmaceutical ingredient.
The tablet is film-coated, oval in shape, and typically marked for identification. It is designed to be swallowed whole with water and is well-tolerated when taken with food.
Pharmacological Action
Pirfenex works by exerting dual effects:
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Anti-fibrotic activity: It inhibits the processes that lead to the development of fibrotic tissue. It interferes with the production and activity of pro-fibrotic growth factors, thereby limiting the proliferation of fibroblasts and the production of collagen in lung tissues.
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Anti-inflammatory activity: It reduces the release of inflammatory mediators, which play a role in damaging lung tissues and initiating fibrotic responses.
By moderating both inflammation and fibrosis, Pirfenex helps delay the decline of lung function, allowing patients to maintain physical activities and daily routines for longer periods.
Indications
Pirfenex 200 mg is prescribed primarily for:
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Idiopathic Pulmonary Fibrosis (IPF)
It may also be explored under professional guidance for other forms of interstitial lung diseases (ILDs), particularly those involving fibrotic progression, although these are considered off-label uses.
Dosage and Administration
The administration of Pirfenex must follow a gradual dose-escalation schedule to minimize side effects and allow the body to adjust to the medication.
Typical Dosing Titration:
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Days 1–7: One tablet (200 mg) three times daily
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Days 8–14: Two tablets (400 mg) three times daily
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Day 15 onwards: Three tablets (600 mg) three times daily (total 1800 mg/day)
Administration Tips:
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Always take Pirfenex with food to reduce gastrointestinal side effects such as nausea or stomach upset.
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Maintain consistent timing for each dose throughout the day.
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Do not crush, chew, or break the tablet.
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If a dose is missed, skip it and resume the regular schedule without doubling the dose.
The full therapeutic dose (usually 1800 mg/day) is achieved after two weeks, unless the physician advises otherwise based on patient tolerance.
Precautions Before Use
Before starting Pirfenex, patients should be evaluated for the following:
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Liver Function: Since the drug is metabolized by the liver, baseline liver enzyme levels must be checked and monitored periodically during treatment.
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Kidney Function: Those with moderate to severe kidney impairment may need dose adjustments or may be advised against use.
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Smoking: Smoking reduces Pirfenidone’s effectiveness. Patients are strongly encouraged to quit smoking before and during treatment.
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Sunlight Exposure: Pirfenex increases skin sensitivity to sunlight. Protective measures such as sunscreen, long-sleeved clothing, and hats are recommended.
Use During Pregnancy and Breastfeeding
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Pregnancy: Pirfenex should only be used during pregnancy if clearly needed and under strict medical supervision. Its safety profile in pregnant women has not been well-established.
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Breastfeeding: It is not known whether Pirfenidone is excreted in human milk. Caution should be exercised, and a risk-benefit assessment should be done by the physician.
Side Effects
Like all medications, Pirfenex 200 mg may cause side effects. However, not all users experience them, and many are mild and manageable with dose adjustment or supportive measures.
Common Side Effects:
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Nausea
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Loss of appetite
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Diarrhea
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Tiredness or fatigue
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Rash or skin redness
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Photosensitivity (sunburn-like reaction)
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Headache
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Weight loss
Less Common but Serious Side Effects:
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Elevated liver enzymes (ALT, AST)
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Severe skin reactions
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Allergic reactions (e.g., swelling of the face or lips)
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Shortness of breath unrelated to IPF progression
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Difficulty swallowing or breathing
In cases of severe adverse reactions, discontinuation or dose reduction may be required.
Drug Interactions
Pirfenex can interact with other medications, which may either increase side effects or reduce its effectiveness.
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CYP1A2 inhibitors (e.g., fluvoxamine): May significantly raise Pirfenidone levels.
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CYP1A2 inducers (e.g., omeprazole, smoking): May reduce Pirfenidone’s effectiveness.
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Antibiotics (e.g., ciprofloxacin): May interact and alter drug levels.
Patients should always provide a complete list of current medications, including over-the-counter drugs, supplements, and herbal products, to avoid harmful interactions.
Overdose and Management
An overdose of Pirfenex 200 mg may cause enhanced side effects such as nausea, dizziness, vomiting, or skin reactions. In the event of an overdose:
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Seek emergency medical attention.
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Supportive care is provided based on symptoms.
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There is no specific antidote; management is primarily symptomatic.
Storage Instructions
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Store Pirfenex tablets at a controlled room temperature, ideally between 15°C and 30°C.
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Keep the tablets in their original packaging, away from moisture and direct sunlight.
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Keep out of the reach of children and pets.
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Do not use tablets beyond their expiration date.
Patient Counseling and Lifestyle Advice
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Stay Active: Gentle physical activity helps maintain lung function.
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Diet: Eat balanced meals, especially if experiencing weight loss or loss of appetite.
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Avoid Alcohol: To minimize liver stress.
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Adherence: Stick to the prescribed schedule for optimal results.
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Routine Monitoring: Regular liver function tests are essential during treatment.
Benefits of Pirfenex 200 mg
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Slows the progression of IPF
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Helps maintain lung function
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Improves exercise capacity
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Provides anti-inflammatory benefits
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Enhances quality of life with long-term use
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Oral and easy to administer
Conclusion
Pirfenex 200 mg plays a vital role in managing Idiopathic Pulmonary Fibrosis, offering patients a better chance at slowing the disease’s relentless progression. With regular use, physician supervision, and adherence to lifestyle modifications, Pirfenex can significantly improve a patient’s ability to function and live a more active life.
While it is not a cure, Pirfenex has transformed the outlook for individuals suffering from this challenging disease. With careful monitoring and support, many patients experience prolonged lung stability and symptom control.
As with all prescription medications, Pirfenex 200 mg should only be used under the guidance of a healthcare provider, who will tailor the dosage and monitor for any side effects or complications. It is a significant step forward in IPF management and continues to offer hope where treatment options were once limited.
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