Glimepiride 3 mg + Metformin 1000 mg
Price range: $80.00 through $150.00
| Quantity Value | Price | Price/Unit | Quantity | Add To Cart |
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| 100 Tablet S | $80.00 | $0.80 / Piece |
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| 200 Tablets | $150.00 | $0.75 / Piece |
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SKU : N/A
Category : Other
Glimepiride 3 mg + Metformin 1000 mg
Glimepiride 3 mg + Metformin 1000 mg is a combination oral antidiabetic medicine used to improve blood-glucose control in people with type 2 diabetes mellitus when diet, exercise, or treatment with a single antidiabetic medicine does not provide adequate control.
It combines glimepiride, a sulfonylurea that stimulates insulin release, with metformin, a biguanide that reduces glucose production by the liver and improves insulin sensitivity. The two medicines work through different mechanisms to provide complementary blood-sugar control.
Uses
This combination may be prescribed for:
- Type 2 diabetes mellitus
- Patients whose blood glucose remains above the individualized target with metformin or another single medicine
- Patients requiring combination therapy for improved fasting and post-meal glucose control
It should be used together with a suitable diet, regular physical activity, weight management, and routine diabetes monitoring.
It is not appropriate for treating type 1 diabetes or diabetic ketoacidosis.
How It Works
Glimepiride
Glimepiride stimulates the pancreatic beta cells to release insulin. Increased insulin helps move glucose from the bloodstream into body tissues.
Because it increases insulin secretion, glimepiride can cause low blood sugar (hypoglycemia), particularly if meals are skipped, food intake is inadequate, alcohol is consumed, or the dose is excessive.
Metformin
Metformin primarily decreases the amount of glucose produced by the liver. It also improves insulin sensitivity, helping muscles and other tissues use glucose more effectively.
Metformin alone generally has a low risk of hypoglycemia, but the risk increases when it is combined with glimepiride.
How to Take
Take this medicine exactly as prescribed by your healthcare professional. It is generally taken with or immediately after a meal, helping reduce gastrointestinal side effects from metformin and reducing the risk of glimepiride-related hypoglycemia.
Swallow the tablet with water. Take it consistently at approximately the same time each day.
Do not skip meals after taking a glimepiride-containing medicine. If you miss a dose, follow your doctor’s instructions rather than taking an additional dose to compensate.
The appropriate regimen depends on blood-glucose levels, kidney and liver function, age, diet, other medicines, and treatment response. Do not increase or decrease the dose without medical advice.
Common Side Effects
Possible side effects include:
- Nausea
- Diarrhea
- Abdominal discomfort
- Bloating or gas
- Headache
- Dizziness
- Increased appetite
- Weight gain
Digestive symptoms are particularly common with metformin and often improve after the body adjusts to treatment.
Hypoglycemia
Low blood sugar is one of the most important risks of this combination, primarily because of glimepiride.
Symptoms may include:
- Sweating
- Shaking
- Hunger
- Fast heartbeat
- Dizziness
- Weakness
- Headache
- Irritability or confusion
- Blurred vision
- Difficulty concentrating
If you are conscious and experience symptoms of hypoglycemia, promptly consume a rapidly absorbed source of glucose according to your diabetes-management plan. Recheck your blood sugar if possible.
Severe hypoglycemia can result in seizures or loss of consciousness and requires emergency medical treatment.
The risk is increased by skipped meals, excessive exercise without adequate food intake, alcohol, kidney or liver impairment, and certain interacting medicines.
Lactic Acidosis
Metformin has a rare but potentially life-threatening complication called lactic acidosis, in which lactic acid accumulates in the bloodstream.
The risk is greater in people with significant kidney impairment and certain serious medical conditions. Seek urgent medical attention for severe weakness, unusual sleepiness, difficulty breathing, persistent vomiting, severe abdominal discomfort, muscle pain, or feeling unusually cold.
Kidney function should be assessed before treatment and monitored periodically.
Vitamin B12 Deficiency
Long-term metformin treatment can reduce vitamin B12 levels in some people. Periodic testing may be considered, especially during prolonged treatment or if symptoms such as anemia, persistent tiredness, numbness, or tingling develop.
Precautions
Tell your doctor if you have:
- Kidney disease
- Liver disease
- Heart failure or significant cardiovascular disease
- A history of severe hypoglycemia
- Adrenal or pituitary disorders
- Heavy alcohol consumption
- Severe infection or dehydration
- Poor nutritional intake
- G6PD deficiency
Older adults may be more susceptible to hypoglycemia and may require careful dose selection and monitoring.
Avoid excessive alcohol because it can increase the risk of hypoglycemia from glimepiride and may increase the risk of lactic acidosis associated with metformin.
Drug Interactions
This combination can interact with medicines that affect blood glucose or alter the effects of glimepiride or metformin. Examples include:
- Insulin and other antidiabetic medicines
- Beta-blockers, which may mask some warning symptoms of hypoglycemia
- Corticosteroids, which can increase blood glucose
- Certain diuretics
- ACE inhibitors and some other medicines that can affect glucose control
- Alcohol
- Warfarin and certain other medicines that may interact with glimepiride
- Iodinated contrast agents used for certain imaging procedures
Always tell your doctor or pharmacist about all prescription medicines, over-the-counter products, vitamins, and herbal supplements you use.
Kidney Function and Contrast Procedures
Metformin is eliminated mainly through the kidneys. Significant kidney impairment may require dose adjustment or make metformin-containing treatment unsuitable.
Before undergoing an examination involving iodinated contrast material, tell the radiology team or doctor that you take metformin. Depending on your kidney function and the procedure, temporary interruption may be recommended.
During severe dehydration, prolonged vomiting or diarrhea, serious infection, or other acute illness, contact your healthcare professional for instructions about continuing treatment.
Pregnancy and Breastfeeding
Glimepiride is generally not preferred during pregnancy because sulfonylureas can cause blood-glucose-related complications in the mother and baby. If you are pregnant or planning pregnancy, consult your doctor about an appropriate diabetes-treatment plan.
Both medicines can pass into breast milk. Breastfeeding patients should discuss treatment with their healthcare professional because sulfonylureas may potentially cause hypoglycemia in a breastfed infant.
Monitoring During Treatment
Your doctor may monitor:
- Fasting and post-meal blood glucose
- HbA1c
- Kidney function
- Liver function when appropriate
- Body weight
- Frequency of hypoglycemic episodes
- Vitamin B12 during long-term metformin treatment when indicated
Regular meals, physical activity, and an appropriate diabetes diet remain important components of treatment.
Storage
Store the tablets at room temperature, protected from excessive heat and moisture. Keep the medicine in its original packaging and out of reach of children. Do not use it after the expiry date.
Conclusion
Glimepiride 3 mg + Metformin 1000 mg combines two complementary medicines for type 2 diabetes. Glimepiride stimulates insulin release, while metformin reduces liver glucose production and improves insulin sensitivity.
The main safety concern is hypoglycemia, particularly when meals are skipped, alcohol is consumed, or other glucose-lowering medicines are used. Metformin also requires appropriate kidney-function monitoring because of the rare risk of lactic acidosis. Take the medicine with meals and exactly as prescribed, monitor your blood glucose regularly, and do not change the dose without professional guidance.
| Pack Size |
100 Tablet/s ,200 Tablets |
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