Zycolchin 0.5 mg
Price range: $4.27 through $110.00
| Quantity Value | Price | Quantity | Add To Cart |
|---|---|---|---|
| 30 Tablet/s | $4.27 |
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| 50 Tablet/s | $6.90 |
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| 100 Tablet/s | $12.80 |
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| 200 Tablet/s | $24.50 |
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| 300 Tablet/s | $35.40 |
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| 500 Tablet/s | $58.00 |
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| 1000 Tablet/s | $110.00 |
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SKU : Zycolchin 0.5 mg
Category : Colchicine , Viral Care
Zycolchin 0.5 mg is used to treat and prevent gout attacks. It reduces inflammation and pain by lowering uric acid buildup in joints and improving mobility.
Zycolchin 0.5 mg is a widely trusted pharmaceutical product used to manage and prevent attacks of gout and Familial Mediterranean Fever (FMF). This oral tablet contains Colchicine 0.5 mg, a well-established compound known for its anti-inflammatory properties. Colchicine, extracted historically from plants like Colchicum autumnale, has a long history of use in treating joint-related conditions. Today, it is used in modern medicine as a specialized agent to control inflammatory reactions associated with gouty arthritis and hereditary auto-inflammatory syndromes.
Zycolchin works by reducing inflammation at a cellular level, specifically by interfering with processes that cause white blood cells to accumulate and trigger painful swelling. Its low-dose formulation makes it ideal for long-term prophylactic use and for patients requiring milder intervention.
Composition and Formulation
Each tablet of Zycolchin contains:
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Active Ingredient: Colchicine 0.5 mg
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Inactive Ingredients: Binders, fillers, and preservatives that aid in tablet integrity and stability.
The formulation is designed for oral administration, with a consistent release and absorption profile that ensures reliable therapeutic levels in the bloodstream.
Therapeutic Indications
Zycolchin 0.5 mg is primarily prescribed for:
1. Gout
Gout is a painful form of arthritis that results from the accumulation of uric acid crystals in joints. Zycolchin is effective for:
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Acute Gout Attacks: Reduces pain and inflammation.
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Chronic Gout Prophylaxis: Prevents recurrent flare-ups by lowering inflammatory triggers.
2. Familial Mediterranean Fever (FMF)
FMF is a hereditary auto-inflammatory disorder, especially prevalent in certain ethnic populations. Zycolchin helps:
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Prevent frequent fever episodes
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Reduce inflammation in joints, abdomen, and chest
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Prevent long-term complications like amyloidosis
3. Pericarditis (Off-label)
Although not officially approved in all regions for this use, Colchicine is sometimes prescribed for recurrent pericarditis, where it helps reduce inflammation around the heart.
Mechanism of Action
Colchicine acts by inhibiting microtubule polymerization, which disrupts the mobility and activity of neutrophils (a type of white blood cell). These cells are central to the inflammatory response seen in gout and FMF. By preventing their accumulation at the inflammation site, Colchicine minimizes tissue swelling, redness, and pain.
Additionally, Colchicine blocks several pro-inflammatory substances, including interleukin-1β, thus reducing the overall systemic response in auto-inflammatory diseases like FMF.
Dosage and Administration
The dosage of Zycolchin varies according to the condition being treated, patient age, kidney and liver function, and response to the drug.
General Dosage Guidelines:
For Gout:
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Acute Attack: Initial dose of 1.0 mg (2 tablets), followed by 0.5 mg every 1–2 hours until pain subsides or maximum dosage is reached (generally not exceeding 6 mg in 24 hours).
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Prophylaxis: 0.5 mg once or twice daily. Often combined with uric acid-lowering therapy such as allopurinol.
For FMF:
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1.0 to 2.0 mg daily in divided doses, adjusted based on individual response and side effects.
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Children may receive lower doses based on body weight.
Administration Instructions:
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Take with or without food, preferably at the same time each day.
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Swallow whole with a glass of water.
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Do not crush or chew the tablet.
Benefits of Zycolchin 0.5 mg
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Targeted anti-inflammatory action: Works on a cellular level without affecting the entire immune system.
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Rapid relief: Especially effective in controlling pain and inflammation during a gout attack.
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Long-term control: Useful in preventing chronic attacks with a low risk of dependency.
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Well-studied: Decades of clinical experience support its safety and efficacy.
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Convenient dosing: Oral tablets are easy to use, making adherence straightforward.
Side Effects
Most people tolerate Zycolchin well, but like all medications, it can cause side effects.
Common Side Effects:
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Diarrhea
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Abdominal cramping
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Nausea
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Vomiting
These side effects often occur at higher doses and subside when the dose is reduced.
Rare but Serious Side Effects:
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Muscle pain or weakness (especially in people also taking statins)
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Neuropathy (numbness or tingling)
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Blood disorders (low white cells, anemia)
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Liver or kidney dysfunction
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Hair thinning (very rare)
If you experience unusual fatigue, infections, or bleeding, consult your healthcare provider immediately.
Precautions and Warnings
1. Kidney and Liver Impairment:
Dose adjustments are often required. Colchicine can accumulate in patients with reduced kidney or liver function, increasing the risk of toxicity.
2. Drug Interactions:
Colchicine interacts with:
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CYP3A4 inhibitors (e.g., clarithromycin, ketoconazole): May increase Colchicine levels.
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P-glycoprotein inhibitors (e.g., cyclosporine, verapamil): Can lead to toxicity.
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Statins and fibrates: May increase risk of muscle injury.
Always inform your doctor of all medications and supplements you are using.
3. Pregnancy and Lactation:
Colchicine crosses the placenta and is excreted in breast milk. Its use during pregnancy or breastfeeding should be considered only if the benefits outweigh the risks.
4. Alcohol Use:
Alcohol can increase uric acid levels and counteract the benefits of gout treatment. Avoid alcohol while using Zycolchin for gout management.
Overdose and Missed Dose
Overdose Symptoms:
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Nausea, vomiting, and severe diarrhea
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Muscle weakness
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Difficulty breathing
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Low blood pressure
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Bone marrow suppression (delayed onset)
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Multi-organ failure (in severe cases)
Seek emergency medical help immediately in case of overdose.
Missed Dose:
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Take as soon as you remember.
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Skip the missed dose if it’s almost time for the next one.
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Do not double the dose.
Storage Instructions
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Store at a controlled room temperature (15°C to 30°C).
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Keep away from moisture, heat, and direct sunlight.
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Keep out of reach of children and pets.
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Do not use expired medication.
Advantages Over Other Treatments
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Zycolchin doesn’t suppress the immune system as broadly as corticosteroids or NSAIDs.
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Less gastric irritation compared to NSAIDs when used at low doses.
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Effective in both acute and chronic settings.
Role in Preventative Therapy
Zycolchin plays a crucial role in preventing flares, especially in patients starting uric acid-lowering therapy. Initiating uric acid-lowering drugs can paradoxically trigger a gout attack, and Zycolchin prevents this reaction when co-prescribed.
In FMF, regular Colchicine use can prevent complications like amyloidosis, which can damage internal organs. Thus, Zycolchin has long-term health-preserving potential in genetically predisposed individuals.
Patient Education and Monitoring
Key Advice:
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Stick to the prescribed dose—more isn’t better.
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Maintain hydration.
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Monitor for signs of muscle weakness or tingling.
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Attend regular check-ups to evaluate liver and kidney function.
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Keep a gout or FMF diary to help assess response to therapy.
Conclusion
Zycolchin 0.5 mg Tablet offers a highly effective and manageable treatment strategy for those suffering from gout, Familial Mediterranean Fever, and other inflammatory conditions. Its well-understood mechanism, combined with a flexible dosing profile and long-standing clinical safety, makes it an ideal option for both short-term symptom relief and long-term disease control.
While patients must remain vigilant about potential side effects, especially at higher doses or in cases of organ dysfunction, Zycolchin continues to be a cornerstone in the management of crystal-induced and inherited auto-inflammatory diseases.
When taken responsibly and under medical supervision, Zycolchin 0.5 mg helps patients regain mobility, reduce discomfort, and live with fewer flare-ups—offering not just relief, but also freedom from the unpredictability of recurring inflammation.
| Quantity Value |
100 Tablet/s ,1000 Tablet/s ,200 Tablet/s ,30 Tablet/s ,300 Tablet/s ,50 Tablet/s ,500 Tablet/s |
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