Afatinib 30 mg
$1,558.25 – $4,471.24
| Quantity Value | Price | Quantity | Add To Cart |
|---|---|---|---|
| 28 Tablet/s | $1,558.25 |
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| 56 Tablet/s | $3,035.02 |
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| 84 Tablet/s | $4,471.24 |
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SKU : N/A
Category : Anti Cancer , Life Saving , Lung Cancer
Afatinib 30 mg is a targeted therapy used to treat non-small cell lung cancer (NSCLC) with specific EGFR mutations, helping slow cancer growth and spread.
A targeted oral drug called afatinib 30 mg is used to treat specific forms of non-small cell lung cancer (NSCLC). It belongs to a class of drugs called tyrosine kinase inhibitors (TKIs) and works by targeting specific epidermal growth factor receptor (EGFR) mutations that are often present in cancer cells. By inhibiting these mutations, it slows or stops cancer cell growth.
Mechanism of Action
Afatinib is an irreversible ErbB family blocker that works by inhibiting the EGFR (Epidermal Growth Factor Receptor) and other members of the ErbB family, such as HER2 (ErbB2), HER3, and HER4. The development and dissemination of cancer cells are facilitated by these receptors. In patients with EGFR mutation-positive NSCLC, it binds to these receptors and blocks the signaling pathways that promote cancer cell division and survival.
Because it binds irreversibly, it provides a sustained suppression of cancer signaling, which can improve clinical outcomes in patients with certain mutations.
Indications and Uses
Afatinib 30 mg is used primarily for:
1. Non-Small Cell Lung Cancer (NSCLC)
According to FDA-approved testing, patients with metastatic non-small cell lung cancer (NSCLC) whose tumors include EGFR exon 19 deletions or exon 21 (L858R) replacement mutations should start using it as their first line of treatment.
It is also used for patients whose disease has progressed despite prior treatment, in specific cases approved by oncologists.
2. Squamous Cell Carcinoma of the Lung
Afatinib may be used in patients with advanced squamous cell carcinoma of the lung who have progressed after treatment with platinum-based chemotherapy.
Dosage and Administration
Standard Dosage:
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The recommended starting dose of Afatinib is 40 mg once daily, but 30 mg may be used in cases where patients experience intolerable side effects or when dose reduction is necessary.
How to Take:
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Afatinib should be taken at least one hour before or two hours after eating.
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Drink a full glass of water and swallow the tablet whole.
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Do not crush or chew the tablets.
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For optimal effects, take it at the same time every day.
Dose Adjustments:
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Dose reduction to 30 mg or even 20 mg may be needed based on side effects such as diarrhea, skin rash, or liver enzyme abnormalities.
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Your physician will keep an eye on your reaction and make any necessary adjustments.
Benefits of Afatinib 30 mg
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Targeted therapy – specifically acts on EGFR-mutated cancer cells
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Proven efficacy – prolongs progression-free survival in EGFR-mutant NSCLC
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Irreversible binding – offers prolonged suppression of cancer signaling
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Once-daily oral tablet – convenient administration
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Option for dose reduction – helps manage side effects without stopping therapy
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Applicable to squamous cell cases – extends therapeutic use
Side Effects
Afatinib can cause side effects in some patients, and the 30 mg dose is often used to help reduce toxicity while maintaining efficacy.
Common Side Effects:
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Diarrhea
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Skin rash or acne
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Stomatitis (mouth sores)
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Dry skin and itching
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Nail infections
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Loss of appetite
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Weight loss
Serious Side Effects:
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Severe diarrhea or dehydration
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Interstitial lung disease
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Liver function changes
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Eye problems (keratitis, dry eye)
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Cardiac issues (left ventricular dysfunction)
Report serious or persistent side effects to your healthcare provider immediately.
Warnings and Precautions
Before beginning 30 mg of Afatinib, let your doctor know if you:
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possess a history of respiratory issues or pulmonary illness
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Have liver or kidney disease
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Are pregnant or breastfeeding
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Are taking other medications (to avoid drug interactions)
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Have heart issues or a history of heart failure
Pregnancy and Breastfeeding:
Effective contraception is necessary both during therapy and for at least two weeks following the last dosage since it can harm an unborn child. Because of the possible risks to the infant, it is not advised while nursing.
Drug Interactions
Afatinib can interact with various medications, including:
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Antacids and proton pump inhibitors – may reduce absorption
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Rifampin, phenytoin, and carbamazepine may decrease levels
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Warfarin and other anticoagulants – increased bleeding risk
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Herbal supplements like St. John’s Wort – avoid use
Always disclose all medications and supplements to your doctor.
Storage and Handling
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Store at room temperature (15–30°C / 59–86°F)
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Protect from moisture and light
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Keep tablets in original packaging until use
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Keep out of children’s and pets’ reach.
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Do not use after the expiry date
Frequently Asked Questions (FAQs)
1. What is Afatinib used for?
Afatinib is used to treat some forms of lung squamous cell carcinoma and non-small cell lung cancer (NSCLC) with particular EGFR mutations.
2. Is 30 mg a standard dose?
The standard starting dose is 40 mg, but 30 mg is commonly used for dose adjustments due to side effects or patient tolerance.
3. Can Afatinib cure lung cancer?
Afatinib does not cure lung cancer but can significantly slow the progression of EGFR-mutated NSCLC and improve survival and quality of life.
4. How long must I take it for?
Afatinib is taken as long as it remains effective and side effects are manageable. Your oncologist will determine the duration.
5. Can I drink alcohol while on Afatinib?
It’s best to avoid alcohol, as it may worsen side effects like liver function changes or dehydration from diarrhea.
Clinical Studies and Efficacy
Numerous clinical trials have assessed afatinib:
LUX-Lung Trials
These pivotal studies showed that Afatinib:
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Improved progression-free survival compared to chemotherapy
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Was effective in EGFR mutation-positive NSCLC
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provided assistance to squamous cell cancer patients following chemotherapy failure.
Afatinib is now a first-line treatment option in many clinical guidelines for EGFR-mutated lung cancer.
Why Choose Afatinib 30 mg?
The 30 mg dose offers a balance between efficacy and tolerability, especially for patients who experience side effects at higher doses. By lowering the dose, patients can:
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Continue benefiting from targeted therapy
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Reduce symptoms like rash or diarrhea
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Maintain a better quality of life during treatment
Patient Support and Counseling
Patients on should receive:
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Regular monitoring (labs, imaging, physical exams)
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Side effect management support
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Nutritional counseling, especially for appetite loss or mouth sores
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Psychosocial support, as cancer treatment can be emotionally challenging
Conclusion
Afatinib 30 mg is a powerful targeted therapy option for patients with EGFR-positive non-small cell lung cancer and certain cases of squamous cell carcinoma of the lung. It works by irreversibly inhibiting multiple cancer-driving receptors and offers a tailored treatment option when dose reduction from 40 mg is necessary.
When taken under the guidance of an oncologist, Afatinib 30 mg allows patients to manage their disease more effectively, often with fewer side effects and greater adherence to treatment. With its established track record, it continues to be a cornerstone therapy in modern precision oncology.
| Quantity Value |
28 Tablet/s ,56 Tablet/s ,84 Tablet/s |
|---|
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