Tolvaptan tablets 30mg
Price range: $100.00 through $425.00
| Quantity Value | Price | Quantity | Add To Cart |
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| 10 Tablet/s | $100.00 |
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| 20 Tablet/s | $190.00 |
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| 30 Tablet/s | $270.00 |
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| 40 Tablet/s | $350.00 |
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| 50 Tablet/s | $425.00 |
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SKU : N/A
Category : General , Tolvaptan
Tolvaptan Tablets 30mg help manage low sodium levels in the blood caused by conditions like hyponatremia, improving fluid balance and overall health.
Tolvaptan 30mg tablets are a pharmaceutical formulation designed to manage specific health conditions by influencing the body’s water balance. Classified as a vasopressin V2-receptor antagonist, this medication plays a critical role in promoting aquaresis—the excretion of free water without significant loss of sodium or potassium. It is particularly useful in treating clinically significant hyponatremia (low sodium levels in the blood) and is also indicated for managing autosomal dominant polycystic kidney disease (ADPKD).
By interrupting the action of antidiuretic hormone (ADH), tolvaptan enables controlled excretion of excess body water, thereby restoring and maintaining appropriate serum sodium levels and slowing kidney cyst growth in ADPKD patients.
Pharmacological Profile
Tolvaptan functions by specifically inhibiting the kidneys’ vasopressin receptors. Vasopressin, also known as antidiuretic hormone, normally promotes water retention by acting on the V2 receptors of renal collecting ducts. Tolvaptan inhibits this mechanism, leading to increased urine production with a high water content, termed “aquaresis.” Unlike traditional diuretics, it does not cause significant sodium or potassium loss, which makes it highly suitable for managing dilutional hyponatremia.
The 30 mg dosage provides a mid-range strength, making it ideal for dose titration during treatment initiation or when transitioning between low and high-dose regimens. The oral formulation ensures ease of administration and predictable pharmacokinetics when taken under medical supervision.
Tolvaptan Tablets 30mg Indications
1. Hyponatremia
Tolvaptan 30mg is widely used in the management of hyponatremia, particularly in patients suffering from conditions like the syndrome of inappropriate antidiuretic hormone secretion (SIADH), heart failure, or liver cirrhosis. In such cases, the body retains water disproportionately, diluting serum sodium levels and leading to symptoms such as headache, confusion, nausea, and fatigue. Tolvaptan corrects this imbalance by promoting the selective removal of excess water, thereby gradually raising the sodium concentration in the blood.
2. Autosomal Dominant Polycystic Kidney Disease (ADPKD)
In patients with ADPKD, tolvaptan has shown the ability to delay the progression of kidney cyst growth and preserve renal function. It works by lowering cyclic AMP levels in renal tubular cells, which slows cyst proliferation and fluid secretion into cysts. The 30 mg dose may be part of a larger twice-daily regimen aimed at sustained suppression of vasopressin’s cyst-promoting effects.
Dosage and Administration
The dosage of Tolvaptan 30mg depends on the indication, patient condition, and tolerance. For hyponatremia, treatment typically begins at a lower dose (15 mg), with gradual escalation to 30 mg if necessary. The dose may be increased in increments until the desired therapeutic effect is achieved. Close monitoring of serum sodium is essential during this period to avoid overcorrection.
In ADPKD, tolvaptan is often started at a split dose such as 45 mg in the morning and 15 mg in the afternoon. The regimen may then be increased to combinations like 60/30 mg or 90/30 mg depending on individual response and tolerability. The 30 mg tablet fits naturally into these dosing schedules and provides a convenient option for stepped titration.
It is recommended to take Tolvaptan tablets in the morning, with or without food, and to maintain proper hydration. Fluid intake should not be restricted, particularly during the initiation phase, to prevent dehydration.Instead of breaking or crushing the tablet, consume it whole with water.
Mechanism of Action
Tolvaptan works by blocking the arginine vasopressin V2 receptors in the kidney’s distal nephron. Under normal circumstances, vasopressin binds to these receptors to initiate water reabsorption via aquaporin-2 channels. By blocking this interaction, tolvaptan effectively reduces water reabsorption, resulting in increased free water clearance from the kidneys.
This mechanism is vital in cases where inappropriate ADH activity causes water retention and low sodium levels. Tolvaptan’s action helps restore the osmotic balance without disturbing electrolyte levels, offering a targeted approach to treatment.
In polycystic kidney disease, V2 receptor antagonism also reduces intracellular cyclic AMP, which in turn inhibits cyst epithelial cell proliferation and fluid accumulation. This dual impact helps slow disease progression while preserving overall kidney function.
Pharmacokinetics
Tolvaptan is well-absorbed when taken orally and exhibits high bioavailability. After two to four hours of ingestion, its plasma concentrations peak. The drug is extensively bound to plasma proteins and is metabolized predominantly in the liver through the cytochrome P450 system, specifically CYP3A4.
The elimination half-life of Tolvaptan is dose-dependent, ranging from 3 to 12 hours, which supports its once or twice-daily dosing schedules. The majority of it is expelled in the feces, with a lesser amount being removed in the urine. Its hepatic metabolism necessitates regular monitoring of liver function throughout treatment.
Precautions and Monitoring
Due to the risk of serious liver injury, it is mandatory to monitor liver function tests before starting therapy, and then regularly throughout treatment. Any signs of hepatic dysfunction, such as fatigue, right upper abdominal discomfort, dark urine, or jaundice, must be reported immediately.
Tolvaptan should not be used in patients with significant hepatic impairment unrelated to ADPKD or in those with conditions requiring rapid correction of hyponatremia. Overly rapid correction can lead to osmotic demyelination syndrome, a potentially fatal condition affecting the central nervous system.
It’s critical to keep an eye on serum sodium levels, particularly in the early stages of treatment. Regular electrolyte assessments help ensure that the drug is effectively raising sodium concentrations without causing harmful imbalances.
Contraindications
Tolvaptan is contraindicated in individuals with:
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Hypersensitivity to the drug or its ingredients
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Inability to sense thirst
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Anuria (inability to produce urine)
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Hypovolemic hyponatremia
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Urgent need for sodium correction
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Concurrent use of strong CYP3A4 inhibitors
Tolvaptan Tablets 30mg Side Effects
Tolvaptan 30mg may have adverse effects, just like any other medicine. Commonly reported effects include:
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Thirst and increased urination
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Dry mouth
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Fatigue
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Polyuria and nocturia
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Nausea and constipation
Less frequent but more severe side effects include:
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Elevated liver enzymes
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Hepatic injury
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Hypernatremia
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Hypotension
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Dehydration
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Osmotic demyelination in case of rapid sodium correction
Patients should be advised to stay well-hydrated and report any unusual symptoms during treatment.
Drug Interactions
Tolvaptan’s metabolism by CYP3A4 means it can interact with other medications that either inhibit or induce this enzyme. Strong inhibitors like ketoconazole, ritonavir, and clarithromycin can significantly increase tolvaptan levels, raising the risk of toxicity. Inducers like rifampin may reduce its effectiveness. Avoiding grapefruit juice is also advised because it is a known CYP3A4 inhibitor.
Combining tolvaptan with other diuretics may potentiate fluid loss and increase the risk of dehydration or electrolyte imbalance. Monitoring is advised when using these combinations.
Storage and Handling
Tablets containing 30 mg of tolvaptan should be kept at room temperature, out of direct sunlight, and away from moisture. Keep them out of children’s reach and in their original packaging. Unused or expired tablets should be discarded properly as per medical guidelines.
Conclusion
Tolvaptan Tablets 30mg offer an effective and targeted approach for treating hyponatremia and managing autosomal dominant polycystic kidney disease. With its selective mechanism, predictable pharmacokinetics, and manageable side effect profile under supervision, it represents a major advancement in nephrology and fluid balance therapy.
Its use, however, demands careful monitoring, patient education, and adherence to clinical protocols to ensure maximum therapeutic benefit while minimizing risks. When prescribed and managed correctly, Tolvaptan can significantly improve the quality of life for patients dealing with complex water balance and renal disorders.
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10 Tablet/s ,20 Tablet/s ,30 Tablet/s ,40 Tablet/s ,50 Tablet/s |
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