Paracetamol (Acetaminophen)
Price range: $30.00 through $240.00
| Quantity Value | Price | Quantity | Add To Cart |
|---|---|---|---|
| 30 Tablet/s | $30.00 |
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| 90 Tablets | $75.00 |
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| 150 Tablets | $130.00 |
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| 300 Tablets | $240.00 |
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SKU : N/A
Category : Pain Killer
Chemical and Pharmacological Profile
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Generic Name: Paracetamol (INN), Acetaminophen (USAN)
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Drug Class: Analgesic (pain reliever) and Antipyretic (fever reducer)
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Molecular Formula: C₈H₉NO₂
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Common Brand Names: Tylenol, Panadol, Calpol, Crocin
Paracetamol works primarily by inhibiting prostaglandin synthesis in the central nervous system (CNS). Unlike NSAIDs (e.g., ibuprofen), it does not have strong anti-inflammatory properties, making it ideal for cases where inflammation is not the main concern.
Mechanism of Action
Paracetamol’s pain-relieving and fever-reducing effects are thought to be due to the inhibition of cyclooxygenase (COX) enzymes, particularly COX-2, in the brain. This inhibition decreases the production of prostaglandins, chemical messengers involved in pain and temperature regulation.
However, unlike NSAIDs, paracetamol does not inhibit prostaglandins in peripheral tissues, which explains its lack of anti-inflammatory effect and lower risk of gastrointestinal side effects.
Medical Uses of Paracetamol
1. Pain Relief (Analgesia)
Paracetamol is used to relieve mild to moderate pain, including:
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Headaches and migraines
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Toothache
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Muscle pain and backache
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Menstrual cramps
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Post-surgical pain
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Osteoarthritis
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Post-immunization discomfort
It is suitable for individuals who cannot tolerate NSAIDs due to stomach ulcers, gastric sensitivity, or asthma.
2. Fever Reduction (Antipyresis)
Paracetamol is highly effective in reducing fever caused by:
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Common cold or flu
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Viral infections like dengue or COVID-19
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Post-vaccination fever (especially in children)
It is often preferred for pediatric fever management due to its safety profile.
3. Combination Therapies
Paracetamol is commonly combined with other ingredients for enhanced effects:
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With caffeine – for stronger relief from headaches or migraines
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With codeine or tramadol – for severe pain management
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With antihistamines or decongestants – in cold and flu remedies
Dosage Guidelines
Adults:
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Typical dose: 500 mg to 1000 mg every 4–6 hours
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Maximum dose: 4000 mg/day (unless otherwise prescribed)
Children:
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Dose based on weight (usually 10–15 mg/kg per dose)
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Given every 4–6 hours, not to exceed 5 doses in 24 hours
⚠️ Always follow medical advice or packaging instructions to avoid accidental overdose.
Forms and Routes of Administration
Paracetamol is available in various forms:
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Tablets or caplets
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Oral suspensions (liquids for children)
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Chewable tablets
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Suppositories (rectal)
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Intravenous injection (IV paracetamol) – usually administered in hospital settings
This wide range makes it suitable for use in infants, children, adults, and elderly patients.
Advantages of Paracetamol
✅ Well-tolerated by most age groups
✅ Minimal side effects when used appropriately
✅ Safe during pregnancy and breastfeeding (with guidance)
✅ No risk of gastric bleeding or ulcers unlike NSAIDs
✅ Compatible with most medications
Side Effects of Paracetamol
Paracetaml is generally considered safe when used correctly. However, side effects may occur, particularly with overdose or long-term use.
Common Side Effects (rare):
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Nausea
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Rash
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Allergic reaction (hives, itching)
Serious Side Effects:
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Liver damage or liver failure (especially in overdose)
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Kidney damage (with long-term use)
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Low blood cell counts (very rare)
Overdose is a medical emergency and may require treatment with N-acetylcysteine (NAC) to prevent liver toxicity.
Warnings and Precautions
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Do not exceed 4 grams (4000 mg) per day in adults.
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Avoid using multiple medications that contain paracetaml to prevent accidental overdose (e.g., cold & flu combinations).
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Individuals with liver disease, alcoholism, or chronic malnutrition should use paracetaml cautiously.
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Inform your doctor before use if pregnant or breastfeeding, though paracetaml is generally considered safe in pregnancy.
Paracetamol vs. NSAIDs (Ibuprofen, Aspirin)
| Feature | Paracetamol | NSAIDs (e.g., Ibuprofen) |
|---|---|---|
| Pain relief | Yes | Yes |
| Fever reduction | Yes | Yes |
| Anti-inflammatory | Minimal | Strong |
| Stomach irritation | Rare | Common |
| Safe in pregnancy | Yes (in moderation) | Not always |
| Risk of bleeding | No | Yes (esp. aspirin) |
Paracetamol is preferred in individuals with gastric sensitivity, asthma, bleeding risk, or when anti-inflammatory action is not required.
Paracetamol in Special Populations
In Children
Paracetamol is often the first choice for fever in children. It is safe, effective, and palatable in syrup form. Always use weight-based dosing and avoid adult formulations.
In Pregnancy and Breastfeeding
Paracetamol is the preferred analgesic and antipyretic during pregnancy. It crosses the placenta but has not been linked to fetal malformations when used in therapeutic doses.
In the Elderly
Well tolerated, but liver function should be considered. Ideal for arthritic pain and fevers in elderly patients who may be sensitive to NSAIDs.
Paracetamol in Viral Illnesses (e.g., COVID-19, Dengue)
Paracetaml has been widely recommended for fever and pain relief in COVID-19 and dengue due to its safety profile and non-thinning effect on the blood. Unlike aspirin or ibuprofen, it doesn’t increase bleeding risk, making it ideal for dengue fever management.
Overdose Risks and Management
Taking too much paracetamol can lead to acute liver failure, which can be fatal. Overdose symptoms may not appear immediately but can include:
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Nausea or vomiting
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Abdominal pain
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Confusion
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Yellowing of the skin (jaundice)
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Dark urine
If an overdose is suspected, seek immediate emergency care. Treatment usually includes activated charcoal and N-acetylcysteine (NAC).
Conclusion
Paracetamol (acetaminophen) is a versatile, effective, and safe medication for managing fever and pain across all age groups. Its gentle profile on the stomach and lack of anti-inflammatory effects make it a better choice than NSAIDs in many situations, especially in children, pregnant women, and patients with gastrointestinal sensitivity.
While it remains one of the safest OTC drugs, responsible usage and dosage awareness are essential to avoid complications such as liver damage. Paracetaml continues to be a cornerstone of modern symptom relief in both clinical and home settings.
| Pack Size |
150 Tablets ,30 Tablet/s ,300 Tablets ,90 Tablets |
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