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Darzalex 100 Mg Injection

$2,200.00$3,300.25

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6 Injection$2,200.00
9 Injection$3,300.25

Darzalex 100 mg (Daratumumab) is a targeted injection therapy used to treat multiple myeloma by binding to CD38 and helping destroy cancerous plasma cells.

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Description

Introduction

Darzalex (daratumumab) is a groundbreaking monoclonal antibody therapy developed to treat multiple myeloma, a cancer of plasma cells in the bone marrow. It targets the CD38 protein, which is highly expressed on myeloma cells, facilitating their destruction. For intravenous infusion, Darzalex comes in 100 mg/5 mL (20 mg/mL) single-dose vial.

Mechanism of Action

Daratumumab binds to CD38, a transmembrane glycoprotein present at high levels on multiple myeloma cells. Upon binding, it induces cell death through multiple mechanisms:

  • Complement-Dependent Cytotoxicity (CDC): Activates the complement system, leading to cell lysis.

  • Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC): Recruits immune effector cells to kill the targeted cells.

  • Antibody-Dependent Cellular Phagocytosis (ADCP): Promotes phagocytosis of myeloma cells by macrophages.

  • Direct Apoptosis: Induces programmed cell death directly.

Additionally, daratumumab modulates the immune system by depleting CD38-positive immunosuppressive cells, enhancing the anti-myeloma immune response.

Indications

The use of Darzalex in adults with multiple myeloma is authorized:

  • Newly Diagnosed Patients:

    • In conjunction with lenalidomide and dexamethasone, or in patients who are not eligible for autologous stem cell transplantation, in conjunction with bortezomib, melphalan, and prednisone.

    • In addition to thalidomide, dexamethasone, and bortezomib for patients who qualify for autologous stem cell transplantation.

  • Relapsed or Refractory Multiple Myeloma:

    • Either in conjunction with bortezomib and dexamethasone for patients who have had at least one previous treatment, or with lenalidomide and dexamethasone.

    • As monotherapy for patients who have had at least three lines of treatment in the past, such as immunomodulatory drugs and proteasome inhibitors.

Dosage and Administration

Darzalex is administered as an intravenous infusion. The recommended dosage is 16 mg/kg of body weight, following a specific schedule:

  • Weeks 1–8: Weekly infusions.

  • Weeks 9–24: Every two weeks.

  • From week 25 onwardEvery four weeks till the illness worsens.

Pre-infusion medications, including corticosteroids, antipyretics, and antihistamines, are recommended to reduce the risk of infusion-related reactions.

Side Effects

Common Side Effects:

  • Reactions to the infusion (e.g., fever, chills, shortness of breath).

  • Fatigue.

  • Nausea.

  • Diarrhea or constipation.

  • Upper respiratory tract infections.

  • Muscle spasms.

  • Back pain.

  • Cough.

Serious Side Effects:

  • Severe infusion reactions, including anaphylaxis.

  • Neutropenia (low white blood cell count).

  • Thrombocytopenia (low platelet count).

  • Anemia.

  • Infections.

Patients should be monitored for these side effects, and supportive care should be provided as necessary.

Contraindications and Precautions

Contraindications:

  • Known hypersensitivity to daratumumab or any of its components.

Precautions:

  • Infusion Reactions: Keep an eye on patients both during and after the infusion, and take medication as prescribed.

  • Hematologic Toxicity: Monitor complete blood counts periodically.

  • Infections: Monitor for signs of infection and manage promptly.

  • Interference with Serological Testing: Daratumumab may interfere with blood typing; inform blood banks prior to transfusions.

Storage and Handling

  • Vials should be kept in refrigerator between 2°C and 8°C (36°F and 46°F).

  • Do not freeze or shake.

  • Protect from light.

Conclusion

Darzalex 100 mg Injection represents a significant advancement in the treatment of multiple myeloma, offering a targeted approach that enhances the body’s immune response against cancer cells. Its integration into various treatment regimens has improved outcomes for many patients. As with all therapies, careful monitoring and adherence to administration guidelines are essential to maximize benefits and minimize risks.

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3 Injection

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6 Injection

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9 Injection

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